Discovery, Annotation, and Functional Analysis of Long Noncoding RNAs Controlling Cell-Cycle Gene Expression and Proliferation in Breast Cancer Cells
1. LncRNA 长度大于200nt的非编码RNA,具有高度细胞特异性,新LncRNA有待发现及研究
2.二代测序技术给LncRNAs的鉴定与注释带来了极大的便利
3.研究表明LncRNA与疾病具有密切关系(细胞核及胞浆LncRNA具有不同的功能)
4.多种癌症的发生于特定的LncRNA密切相关(prostate cancers: the lncRNAs SChLAP1,PCAT-1, PCGEM1, and PRNCR1; breast cancers : BCAR4)
5.乳腺癌发生过程中LncRNA的分子机制暂不清楚